Aciclovir 200 mg. 25 tablets
Aciclovir Actavis contains as active antiviral agent acyclovir. Tone inhibits the multiplication of viruses that cause common diseases in humans such as herpes simplex, herpes zoster, chickenpox (varicella). Ordinary herpes affects mostly skin around the lips, face and mucous membranes of the genitals, causing blisters, accompanied by itching, burning, soreness. Herpes zoster is an acute infectious disease which is characterized by painful, and a characteristic skin rash located (usually in the area of the eyes, in the course of the nerves lying between the ribs), which is caused by the viruses causing chickenpox.
Aciclovir Actavis is applied for the treatment of:
• Simple herpes as the first appearance of the disease, and when it recurs (relapse).
• Small pox (varicella) u shingles.
• Treatment of herpes simplex and herpes zoster infections in patients with severely impaired immunity, such as patients with advanced HIV infection or after bone marrow transplantation.
The product is suitable for protection against recurrence of herpes simplex in patients with preserved immunity, as well as for prophylaxis (prevention) of herpes viral infections in patients with severe immunity.
2. BEFORE YOU TAKE aciclovir Actavis
Do not take Acyclovir Actavis if you are allergic (hypersensitive) to acyclovir, valacyclovir, or any of the other ingredients of Acyclovir Actavis.
Take special care with Aciclovir Actavis
The active substance is eliminated oi body primarily through urine, which is why in patients with impaired renal function, it may accumulate in the body and cause some side effects in the nervous system. Although these effects usually resolve after discontinuation of therapy, Aciclovir Actavis should be used with caution in patients with kidney disease and in elderly patients who may have been some disturbances in the function of the kidneys. These patients require close medical supervision.
During treatment with acyclovir, particularly at high doses need to know that every day should drink enough water and other fluids to ensure the broadcasting of active veshtsstvo urine. This is especially true for older people and those with kidney disease.
Prolonged or repeated courses of acyclovir in patients with serious damage on immunity may lead to the development of viruses with reduced sensitivity to not respond to continued treatment with acyclovir.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
No clinically significant interactions with other drugs acyclovir. Probenecid and cimetidine can slow its transmission through the kidneys. Such an action and mycophenolate mofetil (medicine used in patients who have received organ transplants).
Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine.
Pregnancy: treatment with this product should only be used after a rigorous assessment by a doctor of the ratio between the expected benefit to the mother and the risk to the fetus.
Lactation found that acyclovir passes into breast milk. This requires treatment with this product during lactation is possible only after a rigorous evaluation of the benefit to the mother and risks to the infant. It is recommended that nursing be discontinued while taking acyclovir.
Driving and using machines
No evidence of adverse effects of acyclovir on ability to drive and use machines.
3. HOW TO TAKE aciclovir Actavis?
Always take Acyclovir Actavis exactly as your doctor tells you. If you are unsure ask your doctor or pharmacist.
Treatment of herpes simplex
200 mg (one 200 mg tablet or 1/2 tablet of 400 mg) 5 times a day at an interval of four hours (omitting the night dose). The duration of treatment is five days, while serious infections at the discretion of the physician, it may be extended.
For some patients (eg. Those with pronounced immunity disorders, diseases resulting in reduced absorption of the drug from the intestine), the dose may be doubled. In these patients, the doctor will decide whether it is appropriate intravenous administration of the product.
Treatment should be initiated as soon as possible after the onset of the first signs of infection - itching, burning, blistering.
Protection of recurrence of infection by herpes simplex
Recommended daily dose of 800 mg (4 tablets of 200 mg or 2 tablets of 400 mg) taken as equal single doses in 6 (12) hour period.
Product administration should be interrupted periodically for 6-12 months to take account of possible changes in the course of the disease.
Prevention of herpes simplex in patients with impaired immunity
A single dose of 200 mg (1 tablet of 200 mg, or 1/2 tablet of 400 mg). 4 times daily during 6 hour interval.
In patients with immune deficiency disorders (e. After bone marrow transplantation), or patients with impaired absorption of the drug from the intestine, the single dose may be doubled - 400 mg, administered five times over four hours. In these patients, the doctor will decide whether it is appropriate intravenous administration of the product.
The duration of the application will be determined by the physician.
Treatment of chickenpox and shingles
It is recommended that a single dose of 800 mg (4 tablets of 200 mg and 2 tablets of 400 mg), five times a day during the 4 hour intervals and the duration of treatment 7 days. In patients with immune deficiency disorders (eg. After a bone marrow transplant) or in patients with impaired absorption of the drug from the intestine, the doctor will decide whether it is appropriate intravenous administration of the product.
Treatment should be initiated as soon as possible after the onset of infection.
Treatment of patients with immune deficiency disorders
It is recommended that a single dose of 800 mg (4 tablets of 200 mg and 2 tablets of 400 mg). four times daily during the 6-hour intervals for 6 months. Before being administered tablets containing acyclovir treatment usually starts with at least one month intravenous administration of the product.
Treatment of herpes simplex infection and prophylaxis of herpes simplex infection in patients with impaired immunity
Dosage form (tablets) is unsuitable for children under 6 years. The dosage for children is 20 mg / kg weight, four times daily.
Treatment of varicella (chickenpox)
Children over 6 years - 800 mg four times daily acyclovir. Sick Elderly
The possibility of disturbances in renal function in this category of persons should be taken into account and the dosage to be adjusted accordingly. It is necessary to adopt adequate hydration.
Patients with renal impairment
In these patients require dose adjustment and extending the time between doses, according to the degree of renal impairment.
For the treatment of herpes simplex in patients with severe renal impairment is recommended single dose of 200mg. which is taken at 12 hour intervals.
In the treatment of herpes zoster infections recommended single dose of less than 800 mg, to be taken at 12 hour intervals.
It is necessary to adopt adequate hydration.
If you take more dose Aciclovir Actavis
If you take more than the prescribed dose, contact your doctor or go to the nearest hospital. Feature of his is especially true if you have nausea and vomiting, headache and feel confused.
If you forget to take Aciclovir Actavis
If you forget to take a dose, take it as soon as possible after you remember. Do not take a double dose. to forgotten. Take the next dose at the usual time.
If you stop taking Aciclovir Actavis
Do not stop taking your tablets if you feel better, unless your doctor tells you to.
If you have any other questions on the use of this product, ask your doctor or pharmacist.
4. POSSIBLE SIDE EFFECTS
Like all medicines. Aciclovir Actavis can cause side effects, although not everybody gets them. The following is the frequency with which adverse reactions have been reported:
Common - occurs in more than one patient in 100 and at least one in ten, receiving the product.
Uncommon - occurring in at least one in 1000 and in less than one in 100, taking the product
Rare - appear in at least one of 10 000 in less than one in 1000. The received product
Very rare - occurs in less than 1 patient out of ten thousand, taking the product.
Side effects that may occur while taking the product are:
Blood and lymphatic system
Decrease the number of red (anemia) and white blood cells and the number of blood platelets (thrombocytes)
Immune system disorders:
Anaphylactic reactions (severe allergic reactions. Incl. Allergic shock)
Psychiatric disorders and nervous system disorders
Common: Headache, dizziness
Very rare: Agitation, confusion, uncontrolled dread of limbs, impaired balance and speech, hallucinations, seizures, drowsiness, loss of consciousness and coma
These effects are generally reversible and usually reported in patients with renal impairment and in elderly persons.
Respiratory and lung of violations was
Rare: difficulties in breathing (dyspnea)
Common: Nausea, vomiting, diarrhea and abdominal pain
Rare: Reversible increases in bilirubin and liver enzymes
Very rare: hepatitis (liver inflammation), jaundice
Skin and subcutaneous tissue disorders
Common: Itching, rash (photosensitivity - increased sensitivity to sunlight)
Uncommon: Hives (urticaria) strong connection extensive hair loss of this type of hair loss by taking acyclovir is uncertain.
Rare: angioedema (swelling of the lips, eyes, tongue, throat)
Renal and urinary tract
Rare Very rare: increased blood urea and creatinine Acute renal failure, pain in the kidneys
General disorders and administration site conditions:
Common: Fatigue, fever
If any of the side effects gets serious, or get any side effects not listed in this leaflet, please ask your doctor or pharmacist.
5. HOW TO STORE aciclovir Actavis?
Keep out of the reach of children. Below 25 ('C!
Do not use Acyclovir Actavis after the expiry date stated on the packaging. The expiry date refers to the last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required.
6. FURTHER INFORMATION
What Acyclovir Actavis?
Actavis aciclovir 200 mg tablets
The active substance per tablet is acyclovir 200 mg.
The other ingredients are microcrystalline cellulose, sodium starch glycolate, povidone, magnesium stearate.
Actavis acyclovir 400 mg tablets
Active substance in a tablet is acyclovir 400 mg.
The other ingredients are microcrystalline cellulose, sodium starch glycolate, povidone, magnesium stearate.
Acyclovir Actavis looks like and contents of the pack?
Actavis acyclovir 200 mg tablets - round biconvex, 9 mm in diameter with a white to off-white color.
Actavis acyclovir 400 mg tablets - round flat tablets scored on one side, with a diameter of 13 mm, white to off-white color.