AZAX. 500 mg. 5 tablets

AZAX. 500 mg. 5 tablets
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AZAX is an antibiotic with a broad antibacterial spectrum, which works against most bacterial strains. It inhibits protein synthesis in the bacterial cell wall and thus the ability of the bacteria to grow and multiply. 

AZAX. 500 mg. 5 tablets

 
 
AZAX WHAT IS AND WHAT IT IS USED
AZAX contain the active ingredient azithromycin, which belongs to a new class of macrolide antibiotics, called azalides.
AZAX is an antibiotic with a broad antibacterial spectrum, which works against most bacterial strains. It inhibits protein synthesis in the bacterial cell wall and thus the ability of the bacteria to grow and multiply.
AZAX is indicated for treatment of patients with infections caused by microorganisms sensitive to azithromycin: Gram-positive and Gram-negative aerobic cocci and bacteria, anaerobic organisms, and clinically atypical intracellular microorganisms:
Infections of the upper respiratory tract bacterial pharyngitis (acute inflammation of the swallowing), tonsillitis (tonsillitis), sinusitis (inflammation of the paranasal sinuses (sinuses) and otitis media;
Infections of the lower respiratory tract inflammation of the bronchi and lungs;
Infections of skin and soft tissue erythema chronicum migrans (first Lyme disease - infection after a bite from an infected tick), erysipelas (erysipelas - an acute infectious disease of the skin that is caused by streptococcal infection), impetigo (acute contagious disease skin flowing bubbles which are later covered with crust) and secondary pyoderma (a bacterial infection of the skin, most often caused by staphylococci or streptococci, with major symptom suppuration), acne vulgaris;
Sexually transmitted diseases: uncomplicated urethritis (inflammation of the urethra caused by microorganisms, manifested by itching, burning, pain during urination), cervicitis (inflammation of the mucous membrane of the cervix) caused by Chlamidia trachomatis, Ureaplasma urealyticum and Neisseria gonorrhoeae.

2. BEFORE YOU TAKE AZAX
Do not take AZAX:
if you are allergic (hypersensitive) to azithromycin, erythromycin or any other macrolide antibiotics, or any of the other ingredients of AZAX. An allergic reaction may be recognized by the presence of: rash, itching, redness of the skin and difficulty breathing;
if you are taking medicines containing ergot derivatives because of the theoretical possibility of ergotism (dizziness, nervous disorder, impaired circulation, causing bruising of the limbs).
Take special care with AZAX
Before starting treatment with AZAX tell your doctor if you have:
impaired liver function;
severe renal insufficiency as required special attention.
Use in children and adolescents
For children weighing less than 45 kg is recommended that treatment with suspension.

Application for adult patients
No alteration of dosage in elderly patients with normal renal and hepatic function receiving azithromycin at recommended doses.

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

It is an interaction with concomitant administration of macrolide antibiotics (particularly azithromycin) and the following medicinal products:
Antacids (with increased acidity of the stomach). It is recommended that at least an interval of 2 hours between the application of the azithromycin and any antacid;
Warfarin, or oral coumarin anticoagulants (to prevent blood clotting) - An increased tendency to haemorrhage;
Cyclosporine (in transplant patients with the aim of suppressing the immune system and the prevention of rejection of organ transplants);
Digoxin (arrhythmias and heart failure);
Rifabutin (antibiotic);
Nelfinavir (antiviral medicine - in patients with HIV);
Terfenadine (for treatment of allergy).
Do not take both ergot alkaloids (ergotamine and dihydroergotamine) and azithromycin, because of the theoretical possibility of ergotism.
It is known that the macrolide antibiotics interact with astemizole, triazolam, midazolam. Although there is no evidence of interaction between azithromycin and these drugs in concurrent use is recommended careful control over the patient. No significant interactions with concomitant azithromycin and methylprednisolone, carbamazepine, didanosine, zidovudine.
There are no reported interactions between azithromycin and theophylline, cimetidine.

Taking AZAX with food and drink
AZAX should be administered at least 1 hour before or 2 hours after eating.
AZAX tablets should be swallowed whole.

Pregnancy and lactation
Ask your doctor or pharmacist before taking any medicine.
Before taking AZAX is important to tell your doctor if you are pregnant, planning to become pregnant, breastfeeding or planning to breastfeed.
AZAX should not be used during pregnancy unless clearly necessary. During lactation AZAX should be used only when the benefit to the mother is judged to be greater than the potential risk to the fetus.

Driving and using machines
No data AZAX to affect the ability to drive and use machines.

Important information about some of the ingredients of AZAX
AZAX contains lactose. If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this medicine.

3. HOW TO TAKE AZAX
Always take AZAX exactly as your doctor tells you. If you are not sure, ask your doctor or pharmacist.
AZAX administered once daily by mouth.
AZAX should be administered at least 1 hour before or 2 hours after eating.
AZAX tablets should be swallowed whole.

Adults and adolescents over 16 years of age (over 45 kg)
Indications Recommended Dose / Duration of treatment
Infections of the upper and lower respiratory tract infections and skin and soft tissue infections (excluding erythema migrans and acne vulgaris) 1 tablet AZAX (500 mg of azithromycin) (single dose) for 3 days
Erythema migrans AZAX 2 tablets (1 g azithromycin) once the first day, followed by 1 tablet AZAX (500 mg Azithromycin) from the second to the fifth day as single daily doses
Acne vulgaris AZAX 1 tablet (500 mg of azithromycin in a single daily dose) for 3 days.
Then, 500 mg once a week up to a total dose of 6 g (9 weeks).
The dose of the second week, must be taken 7 days after the first tablet. After 8 weeks should be taken one tablet per week (equal 7-day intervals).
Diseases STDs AZAX 2 tablets (1 g azithromycin) single daily dose
No dose adjustment is required in the elderly.
In mild renal impairment do not require dosage adjustment of azithromycin. In patients with severe renal failure and liver dysfunction azithromycin should be used with caution.

If you take more dose AZAX
If you take more dose AZAX immediately visit the nearest hospital and take a drug or its packaging with you or contact your doctor.
Typical symptoms of overdose with macrolide antibiotics may include reversible hearing loss, severe nausea, vomiting and diarrhea.
Do not exceed the recommended dose and duration of treatment.

If you forget to take AZAX
If you forget to take a tablet, take it as soon as she thought. Take the next dose after 24 hours. Further follow your prescribed treatment.
Do not take a double dose to make up for a forgotten tablet.

If you stop taking AZAX
Do not stop treatment before you have completed the full course of treatment even if you feel better. You may not have healed completely and some of the symptoms to recur.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS
Like all medicines, AZAX can cause side effects, although not everybody gets them.
Adverse events were mostly mild and transient and resolved after discontinuation of the drug.

In this sheet, when the side effects have been described as "common", it means that they were reported in more than 1 out of 100 patients, but less than 1 of the 10 patients.
When side effects are described as "uncommon", this means that they have been reported in more than 1 in 1000 patients but less than 1 in 100 patients.
When side effects are described as "rare", this means that they have been reported in more than 1 in 10 000 patients, but less than 1 in 1000 patients.
When side effects were described as "very rare", this means that they have been reported in less than 1 in 10,000 patients, including some cases not known.

Blood and lymphatic system
Rare: Thrombocytopenia (decreased number of platelets in the blood, which may increase susceptibility to bleeding and bruising), mild and transient neutropenia (decrease in white blood cells), but not confirmed a causal relationship with azithromycin.
Psychiatric disorders
Rare: Aggressiveness, agitation, anxiety and nervousness.
Nervous System Disorders
Uncommon: Dizziness / vertigo, drowsiness, headache, convulsions (established after use of other macrolides), taste perversion, syncope (temporary loss of consciousness followed by spontaneous recovery);
Rare: Paraesthesia (numbness or tingling) and asthenia (weakness, tiredness), insomnia and hyperactivity.
Ear and labyrinth
Rare: It has been found that macrolides cause hearing impairments. In some patients reported hearing impairment, deafness, tinnitus azithromycin in high doses and for prolonged periods of time. The majority of these violations are of a transient nature.
cardiac disorders
Rare: palpitations and arrhythmias including ventricular tachycardia (rapid heart beat) observed after use with other macrolides.
vascular disorders
Rare: hypotension (blood pressure less than normal).
Gastrointestinal Disorders
Common: Nausea, vomiting, diarrhea, stomach discomfort (pain, cramps);
Uncommon: Loose stools, flatulence, indigestion, anorexia;
Rare: Constipation, discoloration of the tongue, pancreatitis (inflammation of the pancreas occurring pain, nausea, vomiting, diarrhea), pseudomembranous colitis (severe diarrhea and severe abdominal cramps).
Hepatobiliary disorders:
Rare: Hepatitis and cholestatic jaundice, including an increase in liver enzymes to rare cases of hepatic necrosis and hepatic failure with fatal outcome.
Skin and subcutaneous tissue disorders
Uncommon: Allergic reactions including pruritus (itching) and rash;
Rare: Allergic reactions, including angioedema (swelling of the face, extremities, lips, tongue and / or throat), urticaria (hives), photosensitivity (skin reaction when exposed to light), serious skin reactions such as erythema multiforme, syndrome of Stevens-Johnson and toxic epidermal necrolysis (blistering of the skin, mouth, eyes and genitals, skin).
Disorders of the musculoskeletal system and connective tissue
Uncommon: arthralgia (joint pain).
Renal and urinary disorders
Rare: Interstitial nephritis (inflammation of the kidneys), and acute renal failure.
Reproductive system and breast disorders
Uncommon: vaginitis (inflammation of the vagina).
General disorders and administration site conditions
Rare: Anaphylactic reactions, including edema (rarely fatal), candidiasis (yeast infections), fatigue, malaise.
If any of the side effects gets serious, or you notice other effects not listed in this leaflet, please tell your doctor or pharmacist.

5. HOW TO STORE AZAX
Keep out of reach of children.
Store in original container.
AZAX not use after the expiry date stated on the carton. The expiry date refers to the last day of that month.

6. FURTHER INFORMATION
What does AZAX
The active substance is azithromycin. Each tablet contains azithromycin dihydrate equivalent to 500 mg of azithromycin.

Other ingredients are:
Tablet core: pregelatinised starch, hydroxypropyl cellulose, sodium lauryl sulfate, croscarmellose sodium, calcium hydrogen phosphate dihydrate, anhydrous colloidal silica, lactose anhydrous, magnesium stearate.
Coating: Hypromellose, microcrystalline cellulose, titanium dioxide (E 171), macrogol stearate.

AZAX looks like and contents of pack
Pack sizes: 3 pieces coated tablets (per card) number 5 tablets (one blister).
Oval, white, film-coated tablets, scored on one side.
 
 
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