AXURA table. 10 mg. 28 tab

AXURA table. 10 mg. 28 tab
€ 89.00
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AXURA belongs to a group of medicines known as anti-dementia drugs.
 
Memory loss in Alzheimer's disease is due to disturbances in the communication signals in the brain. The brain contains so-called N-methyl D aspartate (NMDA)-petsentopi involved in the transmission of nerve signals, which are important for learning and memory



AXURA table. 10 mg. 28 tab
 
WHAT AXURA IS AND WHAT IT IS USED
 
How does Axura:
 
Axura belongs to a group of medicines known as anti-dementia drugs .
 
Memory loss in Alzheimer's disease is due to disturbances in the communication signals in the brain. The brain contains so-called N-methyl D aspartate (NMDA)- petsentopi involved in the transmission of nerve signals , which are important for learning and memory . Axura belongs to a group of drugs called antagonists of NMDA-receptor . Axura acts on these NMDA- receptors , improving the transmission of nerve signals and memory.
 
 
 
What to use Axura:
 
Axura is used for treatment of patients with moderate to severe Alzheimer's disease.
 
 
 
2 . BEFORE YOU TAKE AXURA
 
Do not take Axura
 
• If you are allergic ( hypersensitive) to memantine
 
hydrochloride or any of the other ingredients of the tablets Axura ( see section 6) .
 
 
 
Take special care with Axura
 
• If you have a history of epileptic seizures
 
• If you have recently had a heart attack or stroke if you have congestive heart failure or hypertension (high blood pressure).
 
In these situations the treatment should be carefully supervised, and the clinical benefit of Axura regularly reassessed by your doctor.
 
If you have renal impairment ( kidney problems) , your doctor should closely monitor your kidney function and if necessary adapt the memantine doses accordingly
 
The use of medicinal products amantadine (for the treatment of Parkinson's disease ) , ketamine (a substance that is normally used as an anesthetic) , dextromethorphan (normally used for treatment of cough ) and other NMDA- antagonists, should be avoided .
 
Axura is not recommended for children and adolescents under 18 years.
 
 
 
Using other medicines:
 
Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
 
In particular, Axura may alter the effects of these drugs , and it may be necessary for your doctor to adjust the dose to them
 
- Amantadine, ketamine dextramethorphan
 
- Dantrolene , baclofen
 
- Cimetidine , ranitidine , procainamide , quinidine, quinine , nicotine
 
- Hydrochlorothiazide (or a combination with hydrochlorothiazide )
 
- Anticholinergics ( substances generally used for the treatment of movement disorders or intestinal cramps )
 
- Anticonvulsants (substances that are used for the prevention or treatment of seizures)
 
- Barbiturates (substances that are commonly used to induce sleep )
 
- Dopaminergic agonists (substances such as L- dopa, bromocriptine )
 
- Neuroleptics (substances that are used for the treatment of psychiatric disorders)
 
• oral anticoagulants .
 
 
 
If you go into hospital, let your doctor know that taking Axura.
 
 
 
Taking Axura with food and drink
 
Tell your doctor if you have recently changed or intend to change your diet ( eg from normal diet to strict vegetarian diet) or if you suffer from renal tubular acidosis ( RTA, an excess of acid-forming substances in the blood due to renal dysfunction (poor kidney function) or severe infections of the urinary system ( urinary tract ) , as may be necessary to adjust the dose of the drug.
 
 
 
Pregnancy and lactation
 
Ask your doctor or pharmacist before taking any medicine .
 
Tell your doctor if you are pregnant or plan to become pregnant. Memantine is not recommended for use in pregnant women.
 
Women taking Axura, should not breastfeed .
 
 
 
Driving and using machines:
 
Your doctor will tell you whether your illness allows you to safely drive or operate machinery.
 
Furthermore Axura may change your reactivity which making driving or operating machinery.
 
 
 
Important information about some of the ingredients of Axura:
 
This medicinal product contains lactose. If your doctor has warned you that you have an intolerance to some sugars, contact your doctor before taking this medicine . Your doctor will advise you how to proceed .
 
 
 
 3 . HOW TO TAKE AXURA
 
 Always take Axura, exactly as your doctor tells you . If you are not sure, please ask your doctor or pharmacist.
 
 
 
dosage
 
The recommended dose of Axura for adults and elderly patients is 20 mg once daily. To reduce the risk of side effects, this dose is achieved gradually by the following daily schedule:
 
Week 1 - half a 10 mg tablet
 
Week 2 - one 10 mg tablet
 
Week 3 - one and a half 10 mg tablet
 
Week 4 - 2 tablets of 10 mg once a day, and then
 
The usual starting dose is half a tablet once a day (1x5 mg) during the first week . This is increased to one tablet once per day (1x10 mg) in the second week to 1 and a half tablet once a day on the third week . From the fourth week on, the usual dose is 2 tablets once daily (1 x 20 mg).
 
 
 
Dosage in patients with impaired renal function
 
If you have impaired kidney function, your doctor will decide what dose is appropriate for your condition. The doctor will monitor your kidney function at regular intervals.
 
 
 
application
 
Axura should be administered orally once daily. To benefit from your medicine , you should take it regularly every day at the same time of day . The tablets should be swallowed with some water. The tablets can be taken with or without food.
 
 
 
Duration of treatment
 
Axura as long as it is of benefit to you . Your doctor should assess your treatment on a regular basis .
 
 
 
If you take more Axura than
 
• In general, taking too much Axura should not harm you . You may experience increased symptoms as described in section 4. "Possible side effects" .
 
• If you take Axura at a dose much higher than prescribed , contact your doctor or seek medical advice, as you may need medical help.
 
 If you forget to take Axura
 
• If you find that you forgot to take your dose Axura, wait and take your next dose at the usual time.
 
• Do not take a double dose to make up for a missed dose.
 
If you have any further questions on the use of this product, please consult your doctor or pharmacist.
 
 
 
4 POSSIBLE SIDE EFFECTS
 
Like all medicines, Axura can cause side effects, although not everybody gets them. Generally, adverse reactions were mild to moderate.
 
 
 
Common ( affects 1 to 10 users in 100 ):
 
• Headache, drowsiness , constipation , dizziness, and hypertension .
 
 
 
Uncommon ( affects 1 to 10 users in 1,000 ):
 
• Tiredness, fungal infections, confusion , hallucinations, vomiting, abnormal gait and venous blood clotting (thrombosis / thromboembolism ) .
 
 
 
Very rare ( affects less than 1 in 10,000 users) :
 
• Seizures
 
Not known ( can not be estimated to assess the frequency ):
 
• Inflammation of the pancreas and psychotic reactions. Alzheimer's disease is associated with depression , suicidal ideation and suicide attempts . These events have been reported in patients treated with Axura.
 
If any of the side effects gets serious , or you notice other effects not listed in this leaflet , please tell your doctor or pharmacist.
 
 
 
5 . HOW TO STORE AXURA
 
• Keep out of reach of children. Do not use Axura after the expiry date stated on the carton and blister after " EXP" . Expiry date refers to the last day of that month.
 
This medicinal product does not require any special storage conditions .
 
Medicines should not be disposed of via wastewater or household waste. Consult your pharmacist how to dispose of medicines no longer required . These measures will help to protect the environment.
 
 
 
 6 . ADDITIONAL INFORMATION
 
What Axura contains
 
The active substance is memantine hydrochloride. Each tablet contains 10 mg of memantine hydrochloride equivalent to 8,31 mg memantine.
 
The other ingredients are lactose monohydrate, mikrokristapinna cellulose , silica , colloidal anhydrous , magnesium stearate and talc - the core of the tablet , a copolymer of methacrylic acid - ethyl acrylate copolymer (1:1 ), sodium lauryl sulfate , polysorbate 80, talc , triacetin and simethicone emulsion - in the tablet coating .
 
Axura looks like and contents of the pack
 
Axura film-coated tablets are white to off-white, centrally tapered oblong, biconvex film-coated tablets with a single score line on both sides.

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