AVANDAMET 2 mg. 1,000 mg. 56 tablets

GlaxoSmithKline
AVANDAMET 2 mg. 1,000 mg. 56 tablets
€ 45.00
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Avandamet tablets is a combination of two different medicines called rosiglitazone and metformin. These two drugs are used to treat type 2 diabetes.

AVANDAMET 2 mg. / 1,000 mg. 56 tablets

 
 
What is Avandamet and what it is used
Avandamet tablets is a combination of two different medicines called rosiglitazone and metformin. These two drugs are used to treat type 2 diabetes.
People with type 2 diabetes either do not produce enough insulin (a hormone that controls blood glucose levels) or do not respond normally to the insulin that is produced in their body. Rosiglitazone and metformin work together to allow your body to better use the insulin it produces and it helps to reduce blood sugar to a normal level. Avandamet may be used alone or with supfanipureen product - another medicine to treat diabetes.
 
2 Before you take Avandamet
To cope with diabetes is important to follow your doctor's advice on diet
and lifestyle and taking Avandamet.
 
Do not take Avandamet:
• if you are allergic (hypersensitive) to rosiglitazone or metformin or any of the other ingredients in Avandamet (listed in section 6)
• If you have had a heart attack or severe angina treated in hospital
• if you have heart failure or have had in the past
• if you have severe breathing difficulties
• if you have liver disease
• if you are taking large amounts of alcohol - if you regularly drink a lot, or if you sometimes have periods of high intake of alcohol
• if you have diabetic ketoacidosis (a complication of diabetes causing RAPID WEIGHT LOSS, nausea or vomiting)
• if you have KIDNEY DISEASE
• if you are dehydrated or have very severe infection (see "While taking Avandamet your doctor needs to know" more natatyk in section 2)
• if you are an x-ray with dye injection (see "While taking Avandamet Your baker should know" later in Section 2)
• are breast-feeding (see 'Pregnancy and lactation' later in Section 2).
Consult with your doctor if you think any of these apply to you. Do not take Avandamet.
 
Take special care with Avandamet
Not recommended for use Avandamet in people aged under 18 years due to lack of data on safety and efficacy. If you have been diagnosed with angina (chest pain) or peripheral arterial disease (reduced blood flow to the legs):
Check with your doctor as Avandamet may not be suitable for you.
 
Conditions you must be careful
Avandamet and other medicines used to treat diabetes can make some existing conditions or cause serious side effects. While taking Avandamet should look out for certain symptoms to reduce the risk of any problems. See 'Conditions you need to watch "in section 4.
 
May start ovulating again
In women who are infertile due to a condition affecting their ovaries (such as Polycystic Ovarian Syndrome), may start ovulating again when they start taking Avandamet. If this applies to you, use appropriate contraception to avoid the possibility of an unplanned pregnancy (see 'Pregnancy and lactation' later in Section 2).
Your kidney function will be checked
Your kidneys will be tested at least once a year - more often if you are over 65 or if your kidney function is normal range.
While taking Avandamet your doctor needs to know:
• if you are dehydrated - eg after severe vomiting, diarrhea or fever. This can lead to a large loss of water (dehydration). Check with your doctor as you may need to stop taking Avandamet for a short time.
• if you have an operation under general anesthesia. Your doctor will advise you to stop taking Avandamet at least 48 hours before and after surgery.
• if you are X-ray with an injectable dye. Your doctor will advise you to stop taking Avandamet X-ray before and 48 hours after. The doctor will check your kidney function before you start treatment again.
 
  Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, or if you start taking new ones. This includes herbal medicines and medicines that you buy without a prescription. Some medicines are likely to affect your blood sugar:
• steroids (used for the treatment of inflammation), such as prednisolone or dexamethasone
• Beta-2 agonists (used to treat asthma), such as salmeterol or salbutamop
• diuretics (used for dewatering) such as furosemide or indapamide
• ACE inhibitors (used to treat high blood pressure), or by enalalril kaptoprip
• gemfibrozil (used to lower cholesterol)
• rifampicin (used for the treatment of tuberculosis and other infections)
• cimetidine (used to reduce stomach acid).
Tell your doctor or pharmacist if you are taking any of these medicines. Your blood sugar will be checked and may need dose of Avandamet be changed.
 
Pregnancy and lactation
• Not recommended for use Avandamet during pregnancy. If you are pregnant or may be pregnant, tell your doctor before you start taking Avandamet.
• Do not breast-feed while taking Avandamet. Ingredients can pass into breast milk and may harm your baby.
 
Driving and using machines
This medicine will not affect your ability to drive or operate machinery.
 
Avandamet contains lactose
AVANDAMET tablets contain a small amount of lactose. Patients who are intolerant to lactose or have a rare hereditary problems of galactose intolerance, Lapp lactase deficiency or gpyukozo-galactose malabsorption should not take this medicine.
 
3 How to take Avandamet
Always take Avandamet tablets exactly as prescribed by your doctor. Do not take more than the recommended dose. If you are not sure, ask your doctor or pharmacist.
 
How much to take
The usual starting dose is one combined tablet (2 mg rosiglitazone and metformin 1000 mg) taken twice daily, morning and evening. (You can also take this dose as two tablets of 1 mg / 500 mg twice daily.) After about 8 weeks, your doctor may increase the dose. The maximum dose is 4 mg rosiglitazone and metformin 1000 mg, taken twice daily. (You can also take this dose as two tablets of 2 mg / 500 mg twice daily.)
 
How to take tablets
Swallow the tablets with some water splits. It is best to take Avandamet with food or immediately after meals. This helps to alleviate any problems from the stomach (including indigestion, nausea, vomiting and diarrhea). Take the tablets at the same time each day and follow any dietary advice, if you are given by your baker.
 
If you take more dose Avandamet
If you accidentally take too many tablets, contact your doctor or pharmacist for advice.
 
If you forget to take Avandamet
Do not take a double dose to make up for a missed dose. Take your next dose at the usual time.
 
Do not stop taking Avandamet
Take Avandamet as long as you recommend your doctor. If you stop taking Avandamet, your blood sugar will be monitored and may be unwell. Tell your doctor if you want to stop.
 
4 Possible side effects
Like all medicines, Avandamet can cause side effects, although not everybody gets them.
 
Conditions you must be careful
Allergic reactions: These are very rare in people taking Avandamet. Signs include:
• raised and itchy rash (urticaria)
• swelling, sometimes of the face or mouth (angioedema), causing difficulty in breathing
• collapse.
Immediately contact your doctor if you experience any of these symptoms. Stop taking Avandamet.
Lactic acidosis: Increase the amount of lactic acid in the blood (lactic acidosis) is a very rare side effect of metformin. It most often affects people with severe renal zabopyavane. Symptoms of lactic acidosis include:
• shortness of breath
• feeling cold
• stomach pain, nausea and vomiting.
Immediately contact your doctor if these symptoms popuchite. Stop taking Avandamet.
Fluid retention and heart failure: Avandamet may cause water retention (water retention), which leads to swelling and increase in tegpoto. The additional amount of fluid can worsen existing heart problems or lead to heart failure. This is more likely to happen if you also take other medicines for diabetes (such as insulin) if you have kidney problems or are over 65 years old. Regularly check your tegpoto. If it goes up rapidly, tell your baker. Symptoms of heart failure include:
• shortness of breath, waking up at night short of breath
• Tracks tiredness SPED light physical activity such as walking
• rapid increase in tegpoto
• swelling of the ankles or feet.
Tell your doctor as soon as possible if popuchite any of these symptoms - either for the first time or if they get worse.
Low blood sugar (hypoglycemia):
If you are taking Avandamet with other medicines for diabetes, it is more likely that your blood sugar to drop below normal values. Early symptoms of low blood sugar are:
• shaking, sweating, faintness
• nervousness, palpitations
• hunger.
Weight may increase, leading to confusion and loss of consciousness.
Tell your doctor as soon as possible if popuchite any of these symptoms. You may need the dose of your medicine may be reduced.
Liver problems: Before you start taking Avandamet you will have a blood test to check the function of your liver. This izspedvane can be repeated at regular intervals. Signs of liver problems may be:
• nausea and vomiting
• stomach (abdominal) pain
• loss of appetite
• dark urine.
Tell your doctor as soon as possible if you experience any of these symptoms.
Eye problems: Swelling of the retina at the back of the eye, which may cause blurred vision (macular edema) can be a problem for people with diabetes. Rarely new cases or worsening of macular edema in people taking Avandamet and similar medicines.
Discuss with your doctor if you have concerns about your eyesight.
Broken bones: For people with diabetes may experience bone fractures. The probability of this spuchi is greater in women taking rosiglitazone for more than one year. The most common are fractures of hodipoto, wrist and hand.
Very common side effects
These may affect more than 1 in 10 patients, "stomach pain, nausea, vomiting, diarrhea or loss of appetite.
Common side effects
These may affect up to 1 in 10 people:
• bopka chest (angina)
• broken bones
• reduce the number of blood cells (anemia) 'slight increase in blood cholesterol, increased levels of fats in the blood
• weight gain, increased appetite
• dizziness
• constipation
• lower blood sugar levels compared with normal levels (hypoglycemia)
• swelling (edema) due to fluid retention
• metallic taste in the mouth. Rare side effects
These may affect up to 1 in 1000 patients: 'fluid in the lungs (pulmonary edema) causing breathlessness
• heart failure
• swelling of the retina in the back of the eye (macular edema)
• liver is not functioning as it should (elevated liver enzymes).
Very rare side effects These may affect up to 1 in 10,000 patients:
• allergic reactions
• inflammation of the liver (hepatitis)
- Reduced levels of vitamin B12 in the blood
• rapid and excessive weight gain due to fluid retention
• increase of lactic acid in the blood.
 
If you get side effects
Tell your doctor or pharmacist if any of the side effects gets serious or troublesome, or if you notice other effects not listed in this leaflet.
 
5 How to store Avandamet
Keep out of reach of children. Avandamet Do not use after the expiry date stated on the pack. This medicine does not require any special storage conditions.
If you have any unwanted tablets, do not waste water or household waste. Ask your pharmacist how to dispose of tablets you. These measures will help to protect the environment.
 
b. Additional information
 
What does Avandamet
The active substances are rosiglitazone and metformin. Avandamet tablets come in different strengths of the active substances. Each tablet contained 1 mg of rosiglitazone and 500 mg of metformin, or 2 mg of rosiglitazone and 500 mg of metformin, or 2 mg of rosiglitazone and 1000 mg of metformin, or 4 mg rosiglitazone and 1000 mg metformin.
The other ingredients are: sodium starch glycollate, hypromellose (E464), microcrystalline cellulose (E460), lactose monohydrate, povidone (E1201), magnesium stearate, titanium dioxide (E171), macrogol, yellow or red iron oxide (E172).
 
 
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